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KMID : 0363620080290040205
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Journal of Korean Oriental Medicine
2008 Volume.29 No. 4 p.205 ~ p.212
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Effect of LI4-LI11 Transcutaneous Electrical Nerve Stimulation on Regional Cerebral Blood Flow in Healthy Human Using SPECT and Statistical Parametric Mapping
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Moon Sang-Kwan
Cho Ki-Ho
Bae Hyung-Sup
Jeong Dong-Won
Park Sung-Wook
Park Jung-Mi
Kim Deog-Yoon
Kim Young-Suk
Jung Woo-Sang
Ko Chang-Nam
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Abstract
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Background and purpose: So far it was reported that acupuncture increased cerebral blood supply and stimulated the functional activity of brain nerve cells. A previous study demonstrated a correlation between LI4-11 electro-acupuncture (EA) and rCBF increase in frontal lobe. However, there remained a need to study further using various controls in acupuncture research. Transcutaneous electrical nerve stimulation (TENS) has been used as a non-invasive control in acupuncture study. This study was to evaluate the effect of LI4-LI11 TENS on regional cerebral blood flow (rCBF) in normal volunteers using single photon emission computed tomography (SPECT) and statistical parametric mapping (SPM).
Methods: In the resting state, brain SPECT scans were performed on 10 normal volunteers (9 males, 1 female, mean age 26.60.5 years; age range from 26 to 27 years). On the other day, 7 days after the resting examination, 15 minute TENS were applied at LI 4 and LI 11 on the right side of the subjects. Immediately after LI4-LI11 TENS, the second SPECT images were obtained in the same manner as the resting state. Significant increases and decreases of regional cerebral blood flow after LI4-LI11 TENS were estimated by comparing their SPECT images with those of the resting state using paired t statistics at every voxel, which were analyzed by statistical parametric mapping with a threshold of p = 0.001, uncorrected (extent threshold: k=100 voxels).
Results: TENS applied at right LI4-LI11 increased rCBF in the left somatosensory association cortex (Brodmann area 5, 7). However there was no area where LI4-11 TENS decreased rCBF.
Conclusion and suggestions: These results demonstrate that right LI4-LI11 TENS increased rCBF only in corresponding somatosensory association cortex, which was different from the previous results using LI4-11 EA. It is suggested that there be a different mechanism between TENS and EA.
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KEYWORD
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Transcutaneous electrical nerve stimulation(TENS), LI4, LI11, regional cerebral blood flow, SPECT, SPM(statistical parametric mapping)
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